wide spectrum of mutations in the beta-globin gene causing beta-thalassemia major in southwest iran

Wide Spectrum of Mutations in the Beta-Globin Gene Causing Beta-Thalassemia Major in Southwest Iran

Background and Aim: Beta-thalassemia ( -thalassemia) is characterized by the reduced synthesis of the hemoglobin beta chain. Nowadays, more than 200 disease-causing mutations in beta-globin ( -globin) gene have been identified. Betathalassemia is the most common monogenic disease worldwide and one of the widespread hereditary disorders in Iran. Considering the vast spectrum of beta-thalassemia ...

THE SPECTRUM OF BETA – THALASSEMIA MUTATIONS IN IRAN

Molecular Spectrum of Beta-Globin Mutations in Transfusion-Dependent Patients with Thalassemia in Qazvin Province, Iran

Background: Beta thalassemia is a common inherited disease, resulting from one or more of 200 different mutations in the beta-globin gene. Qazvin province has attracted migrations of several different populations due to industrialization during the past five decades. The aim of this study was to define the molecular spectrum of beta-thalassemia mutations in Qazvin province. Methods: Ethylen dia...

Beta Globin Frameworks in Thalassemia Major Patients from North Iran

OBJECTIVE Four combinations of five neutral sequence changes at rs713040, rs10768683, rs7480526, rs7946748, and rs1609812 occurring in the human beta globin gene defined as frameworks have been reported in beta globin gene. Here we report for the frequency of these frameworks in thalassemia major patients of North Iran. METHODS Beta globin gene frameworks of 46 thalassemia major patients of N...

Molecular Spectrum of Beta-Globin Mutations in Transfusion-Dependent Patients with Thalassemia in Qazvin Province, Iran

Background: Beta thalassemia is a common inherited disease, resulting from one or more of 200 different mutations in the betaglobin gene. Qazvin province has attracted migrations of several different populations due to industrialization during the past five decades. The aim of this study was to define the molecular spectrum of beta-thalassemia mutations in Qazvin province. Methods: Ethylen diam...

the spectrum of beta – thalassemia mutations in iran

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